Tuesday, February 28, 2012

Cell membranes: way cooler than the wall of China


Cell membranes are one of the tiny wonders of the world. More than just a barrier, they selectively keep things out or let things in to the cell. They have components which identify the cells they protect, receive signals that change what the cell is doing, and send out signals as well.

But what is more amazing is that they are self assembling. If you have a test tube with the molecules that make up a cell membrane mixed evenly in water, you'll find that they quickly form up into spheres of cell membrane. It's one of those things that is both simple and complex. I still have to admit to being a bit awed by them.

The main ingredients of a cell membrane are phosphoglycerides (more commonly known as phosphlipids). There are several versions, but their main construction is a single phosphate head and two fatty acid tails. The phosphate head likes to be around water and mixes with it regularly. The fatty acids are basically oil, and try to avoid water. When you mix these molecules up randomly in water, they come together in a double layered sheet of molecules with the water loving phosphate heads spread out on the outside and the water avoiding tails bunched up on the inside. Beautiful!

Only small molecules such as water, carbon dioxide, and oxygen can pass through membranes made of just phospholipids. These substances enter or exit the cell by diffusion, which basically means things bumping around each other enough that they get spread out evenly. Laws of probability and all that. But cells may need to ingest large molecules such as sugars and proteins. And they may want to keep a concentration of some substances higher or lower in the cell than its surrounding environment.

For this, there are proteins that imbed themselves all the way through the membrane, called integral proteins. Some of these proteins are just pores that certain molecules can fit through. This is how glucose enters the cell. A cell is constantly breaking down glucose to create energy, so there is usually less glucose in the cell than outside of it (the cell is always breaking down glucose to create energy), so it naturally diffuses into the cell. But because a glucose molecule is so big, it must move through the transport proteins in the membrane. No energy is needed to let these kinds of molecules pass.
But some proteins are pumps that actively move molecules in or out. A good example of this are the mineral salts that plants need. These minerals are in a lower concentration in the soil or water than in the cell. To absorb the minerals, the plant cell must use active pumps to keep a higher concentration.

Other integral proteins receive signals which don't have to enter the cell to affect it. These special signal molecules will change the shape of the protein when they attach to it. On the inside of the cell, this shape change starts a chain reaction which causes the cell to either start producing something, stop producing something, or in the case of muscle cells, to change shape.

Some proteins might be stuck to just the surface or partway through a membrane. These peripheral can act as identifiers. In blood cells, surface proteins determine the blood type.

There is a lot more to cell membranes, far more than can be covered in one post or even a series of posts. They are an essential component of all biological life, as important as DNA. Not only do they protect the cell from the outer environment, they protect the cells organelles and store molecules that they don't want to use yet. They can store things for later use, which would otherwise be quickly metabolized in the cell's cytoplasm.

We are learning from these natural technologies. Scientists have now created artificial membranes, an important step to creating artificial life forms. This could have applications in medicine, building, convenience, and many other things (some of them admittedly scary but that's another post). Other technologies which take their cue from the cell membranes are the liposomes found in our face lotions.  Another possible technology  is protecting buildings. While we'll still face pitfalls and dangers, I firmly believe that learning from nature and protecting it, rather than trying to circumnavigate it will propel us into a better world.

Saturday, February 25, 2012

The infamous first post

You know that one where we break the ice, and I tell you why I'm here and what I'm blogging about? That's this post. Sometimes I wish I could be more clever or interesting about these things, but I'm pretty clever about a few other things so it all evens out.

I'm in the middle of writing a book called The Nanotech In You which is under review at an editor's desk. It's a molecular biology tour of your body.

Why? Two reasons. First of all, molecular biology both fascinating and beautiful. Everything our body does is at a basic level an intricate dance between atoms and molecules. Second, if we truly want to understand our bodies and take control of our health, we need to know what's going on under the hood. Our organs work because of what our cells do, which work because of what the molecules inside them do.

I fell in love with molecular biology the day I saw a diagram of a cell membrane. This was a lot more detailed information than just "you are made up of molecules" or even "cells are made up of molecules". This showed what they were, and how they worked. Then I learned about protein creation and the genetic code. The prospect of little computers and little robots inside all of our cells boggled the bigger bio-computer in my skull. Have a genetic problem? It's really a problem with creating some protein you need somewhere. Knowing what that is means we can learn how to fix it.

So, the next post will be about cell membranes. Posts after that may include other explorations of cells, demystifying proteins, bios of dead scientists, cool dead science theories, articles for regular people about current advances in molecular biology and nanotechnology, and whatever other scientific awesomeness takes my fancy.

Mycoplasma mycoides was painted by David S. Goodsell, a fantastic artist/scientist. You can learn more about all of the detail shown in this watercolor here.